What Are “Zombie Cells” & Why They Cause Wrinkles
As we age, our skin accumulates senescent cells—cells that have stopped dividing but refuse to die. These dysfunctional “zombie cells” release inflammatory molecules known as SASP (Senescence-Associated Secretory Phenotype), which:
⚬ Break down collagen
⚬ Disrupt surrounding healthy cells
⚬ Trigger chronic inflammation
⚬ Lead to sagging, wrinkles, and rough skin texture
Addressing senescent cells is key to rejuvenating aging skin at its biological root.
Enter Fisetin: A Natural Senolytic from Fruits
Fisetin is a plant-based flavonoid found in strawberries, apples, and persimmons. What sets it apart? Fisetin is a senolytic, meaning it can selectively destroy senescent cells without harming healthy tissue.
In a groundbreaking 2024 study, researchers tested fisetin on human skin grafts to evaluate its anti-aging potential.
The Study Findings: Rejuvenation from Within
Published in Biogerontology (2024), the study revealed powerful skin benefits:
⚬ Targeted Senolysis – Fisetin effectively cleared senescent fibroblasts in skin
⚬ Collagen Regeneration – Increased density of Collagen I, vital for firmness
⚬ Reduced Inflammation – Lowered SASP molecules and collagen-degrading enzymes
⚬ Excellent Safety Profile – No adverse effects observed in skin tissue
These results show fisetin works at the cellular level—restoring skin health by eliminating the very cells that age it.
How Fisetin Improves Skin Quality
(1) Reduces Wrinkles & Sagging
⚬ By clearing senescent cells and reducing collagen breakdown, fisetin promotes skin firmness and elasticity.
(2) Calms Inflammation
⚬ Suppresses SASP cytokines that contribute to redness, irritation, and slow skin regeneration.
(3) Stimulates Regeneration
⚬ Creates space for healthy, youthful cells to take over, restoring vibrance and clarity to the skin.
AgeReverse™ Solutions Featuring Fisetin
At AgeReverse™, we integrate fisetin into both topical and internal anti-aging protocols:
⚬ Senolytic Solution – Targets senescent skin cells to reduce wrinkles and restore texture
⚬ Resurge Supplement – Combines fisetin with quercetin, NMN, and astragalus for full-body senolytic effects
These dual-action therapies fight aging from outside-in and inside-out—addressing Cellular Senescence, one of the 12 Hallmarks of Aging.
Scientific Corner: Fisetin’s Role in Skin Longevity
Senescent cells increase with age and contribute to skin deterioration. This 2024 study confirmed that fisetin can:
⚬ Selectively eliminate dermal senescent fibroblasts
⚬ Decrease pro-inflammatory and collagen-degrading markers
⚬ Restore collagen levels and improve elasticity
This positions fisetin as a first-in-class natural senolytic for cosmetic and therapeutic use in dermatology.
Ready to Fight Wrinkles at the Root?
Break free from creams that only mask aging. Fisetin fights the cause, not just the symptom. Our Bionic Face Cream contains Fisetin that provides intense hydration, skin renewal, and long-term protection against aging.
Restore Youthful Vitality with Resurge
Take control of aging with Resurge, your ultimate anti-aging & longevity supplement. Experience the benefits of science-backed ingredients that nourish your body from the inside out.
